1KE8 is a Cyclin-dependent kinase (CDK) that belongs to a family of protein kinases. CDKs are considered a potential target for anti-cancer medication. Quinoxaline and its derivatives are an important class of benzoheterocycles displaying a broad spectrum of biological activities which have made them privileged structures in pharmacologically active compounds. Modification in their structure has offered a high degree of diversity that has proven useful for the development of new therapeutic agents having improved potency and lesser toxicity. In the present work, attempts were made to identify leading quinoxaline moieties as candidate drugs against 1KE8 by carrying out docking experiments with 46 analogues and assigning docking scores. Structural features of the above quinoxaline analogues will be presented with a view to arrive at potential drug target for 1KE8.