The most important drawback in cryosurgery is insufficient or inappropriate freezing which will not completely destroy the target tissues tumor, and as a result, it may lead to tumor regenesis and thus result in failure of treatment. The surrounding healthy tissues may suffer from serious freeze injury due to unavoidable release of a large amount of cold from the freezing probe. To solve this problem, a new technique called cryonanosurgery is introduced in which nanoparticles are mixed with cryogens to maximize the freezing and there by minimize surrounding healthy tissues from being frozen